The study results suggested that induction of ANGPTL8 protein may have a moderate anti-hepatocarcinoma effect via balancing of Wnt signaling regulators, however, its action mechanisms are still unknown and further detailed cellular and molecular studies especially on the protein network connection between HCC, MtS factors, and Wnt signaling pathway are necessary. The gene discussed is ANGPTL8; the disease is hepatocellular carcinoma.