In our study, to evaluate the role of inflammatory cytokines and micro-RNAs in the etiology of PVC-induced cardiac dysfunction (PIC), we compared plasma levels of TNF-α, IL-6, IL-10 and IFN-γ by flow cytometry and ELISA, and mRNA by qPCR, and also abundance of miR-155 and miR-146abetween patients with PIC and patients with PVCs but preserved cardiac function. The gene discussed is IL10; the disease is ventricular ectopy.