AD develops as a result of multiple factors including aging over 65 and having apolipoprotein E (APOE) ε4 gene, family history, mild cognitive impairment (MCI), cardiovascular disease risk factors (e.g. smoking, obesity in midlife and diabetes, midlife hypertension) and lower educational attainment (1). The gene discussed is APOE; the disease is obesity due to melanocortin 4 receptor deficiency.