TNF and Schnyder corneal dystrophy: As shown in Figure 3, compared with the AP rats of the SCD group, expressions of TLR4, necroptosis marker (RIP3), expression and nuclear translocation of NF-κB p65, and expression of inflammatory cytokines (TNF-α) in the pancreas were noticeably increased in the HFD group as the time goes (P < 0.05).