LDLR and Glucose intolerance: Ghosh et al. [23, 24] reported that curcumin (100 mg/kg per day BW, 6 weeks) could improve the function of the intestinal barrier preventing glucose intolerance, as well as decreasing circulatory intestine-derived lipopolysaccharide (LPS), thus ameliorating aortic lesion in LDLR−/− mice.