Besides, Zingg et al. [25] found that curcumin could restore the suppression of cyclic adenosine monophosphate (cAMP) induced by HFD in the liver and adipose tissue (but not in the brain, skeletal muscle, spleen, and kidney), thus activating the cAMP/PKA/CREB pathway as well as strengthening lipolysis and fatty acid beta-oxidation in the tissues and contributing to its hypolipidemic effects and improvement of aortic atherosclerosis. This evidence concerns the gene CREB1 and aortic atherosclerosis.