Although, there were few reports on the directed interaction of PIM1, CYP1B1, HSPA2, and osteoarthritis, the docking of PIM1-quercetin, CYP1B1-quercetin, and HSPA2-quercetin may play important roles during the treatment of osteoarthritis by Achyranthes bidentata. The expression levels and activities of PIM1, CYP1B1, and HSPA2 in the animal models and clinical samples have been arranged into our next research plan. Here, PIM1 is linked to osteoarthritis.