In addition, miRNA target prediction algorithms and GO enrichment analysis revealed that SMARCA5, MBD3, VPS53, and EHD4 may mediate the regulation of miR-4701-3p and miR-4793-3p on CRC cell apoptosis, which targets ATP-dependent chromatin remodeling pathway and endocytic recycling pathway. Here, EHD4 is linked to colorectal carcinoma.