To investigate the underlying mechanism of miR-4701-3p and miR-4793-3p on CRC cell apoptosis, we screened 62 common targets of miR-4701-3p and miR-4793-3p through mirTarBase including SMARCA5, MBD3, VPS53, EHD4, and so on. The gene discussed is EHD4; the disease is colorectal carcinoma.