Finally, we used miRNA target prediction algorithms and GO enrichment analysis and revealed that SMARCA5, MBD3, VPS53, and EHD4 are estimated to mediate the regulation of miR-4701-3p and miR-4793-3p on CRC cell apoptosis, which targets ATP-dependent chromatin remodeling pathway and endocytic recycling pathway. This evidence concerns the gene MBD3 and colorectal carcinoma.