For example, miR-375 inhibits CRC cell proliferation mainly through targeting both JAK2/STAT3 and MAP3K8/ERK signaling pathways (Wei et al., 2017), miR-30a regulates cell proliferation and tumor growth of CRC by targeting CD73 (Xie et al., 2017), miR-374b regulates CRC cell apoptosis (Gong et al., 2017). This evidence concerns the gene MAP3K8 and colorectal carcinoma.