FCN3 and hepatocellular carcinoma: In an urge to identify a manageable subset with the minimum number of genes from this list that have a high discriminatory power, we further identified three genes signature-set containing CLEC1B, FCN3, and PRC1. This “three-genes based HCC biomarker” has predictive accuracy of 95–98% and AUROC 0.96–0.99 on the training and all three independent validation datasets.