There are increasing evidence prove that the expression of TNFRSF12A is elevated in various cancers, including breast cancer (Willis et al., 2008), glioma (Tran et al., 2006), esophageal adenocarcinoma (Watts et al., 2007), pancreatic cancer (Han et al., 2002), and HCC (Li et al., 2013; Wang et al., 2017). Here, TNFRSF12A is linked to hepatocellular carcinoma.