While targeted cleavage of either DNMT1 or DNMT3b has little effect on DNA methylation and growth in colon cancer HCT116 cells, simultaneous inactivation of both the methyltransferases results in hypomethylation of a wide range of genomes (Rhee et al., 2002).In this study, we analyzed the correlation between five DNA methyltransferases (DNMT1, DNMT2, DNMT3A, DNMT3B and DNMT3L) and TNFRSF12A expression data from 15 alcoholic hepatitis patients in the GSE28619 dataset. This evidence concerns the gene DNMT3L and alcoholic hepatitis.