Moreover, only the expression of DNMT3L was positively correlated with the methylation level of cg00510447 and cg26808293 (r >0.40, p < 0.001) (Figure 5C).Compared to alcoholic HCC patients, there was no DNA methylases to be identified have correlation with the expression of TNFRSF12A and DNMT3L expression was not correlated to cg00510447 methylation level in non-alcoholic HCC patients (p > 0.05). This evidence concerns the gene DNMT3L and hepatocellular carcinoma.