IFNG and systemic lupus erythematosus: Studies aimed in evaluating the effects of Lactobacillus rhamnosus and Lactobacillus delbrueckii in pristane-induced BALB/c mouse model of SLE showed that the immune-regulatory probiotics led to reduction in autoantibodies, decreased population of Th1-Th17 cells and reduced IFN-γ and IL-17, suggesting the usefulness of these probiotics in the management of SLE (35).