Herein we utilized this inducible model in WT C57BL/6j (B6) mice to determine if topical TLR7 agonism triggered significant autoimmune-mediated nephritis, since data on this is lacking in the prior publications, and we additionally tested whether it accelerates disease expression in lupus-prone NZM2410 mice. The gene discussed is TLR7; the disease is systemic lupus erythematosus.