LDLR and atherosclerosis: Our finding that atherosclerosis is reduced following B cell deficiency arising from genetic deficiency of the Ig heavy chain in μMT−/−ApoE−/− mice is at variance with a previous report that atherosclerosis is increased in LDLR−/− mice rendered chimeric for μMT by lethal irradiation and bone marrow transplantation (36) to induce B cell deficiency.