To investigate the influence of inflammasome components in inducing obesity in response to HFD, C57/BL6 WT, Caspases 1/11−/−, and Nlrp3−/− mice were submitted to SFD or HFD for 3 months, with weekly monitoring of weight gain (Figure 1A). The gene discussed is CASP1; the disease is obesity due to melanocortin 4 receptor deficiency.