NLRP3 and steatosis: Corroborating with studies of Wang et al. (13) and Kimura et al. (29) that showed the susceptibility of Caspases 1−/− mice to gain more weight than WT mice, we further showed here an increase in steatosis levels in the liver and difference in the liver global lipid profile in Caspases 1/11−/− and Nlrp3−/− mice fed a SFD and a HFD.