- Antiangiogenic factors, such as soluble fms-like tyrosine kinase 1 (sFlt1) and soluble endoglin (sEng) are released by the placenta into maternal blood and cause widespread endothelial dysfunction - Peripartum cardiomyopathy (PPCM), a disease involving the dysregulation of the PRL/vasoinhibin axis, shows a strong epidemiological relationship with PE, which suggests shared pathogenesis. This evidence concerns the gene PRL and endothelial dysfunction.