When a large cohort of pre-existing heart failure patients (Pen Heart Failure Study) evaluated for thyroid hormone status and CV composite endpoints, including ventricular assist device placement, heart failure, heart transplant or death, significant associations were noted: a three-fold increase in the risk of composite end point, if TSH ≥ 7and a two-fold increase, if there was isolated low T3 (81). Here, TG is linked to heart failure.