As can be seen in Figure 1A, the rise of IL-1β was observed at day 7 pi, probably constituting the main stimulus for ACTH-triggered CT synthesis in the initial response, whereas in more advanced infection, ACTH release seems not to be fueled by IL-1β (the same was true for TNF-α, IFN-γ, and IL-6). Here, IL1B is linked to infection.