Within the CAS group, LDL-C, TNF-α, and PTX3 were significantly elevated in the SS group (p = 0.049, 0.002, 0.001, respectively) compared to the MS group, however no statistical difference infamily history of cerebrovascular disease was noted between these two groups (p = 1.000) (Table 2). Here, COG2 is linked to cerebrovascular disorder.