HSP90B2P and early-onset autosomal dominant Alzheimer disease: These include, (1) Exercise, sufficient to raise core body temperature, is currently recommended for people with neurodegenerative disease (e.g., Parkinson’s and Alzheimer’s diseases) as it has been shown to improve their symptoms; (2) Elevated HSP levels have been identified as a therapeutic target to reduce protein aggregation and toxicity; and (3) Exercise and body warming have been shown to elevate HSP expression in healthy adults.