HSP90AA1 and neurodegenerative disease: The 70 kDa (HSPA) and 90 kDa (HSPC) family of HSPs, hereafter referred to as HSP70 and HSP90, are generally the most widely studied responders to thermal stressors and are likely of most relevance within the field of heat therapy and heat adaptation for neurodegenerative disease (Luo et al., 2010; Fontaine et al., 2016; Lackie et al., 2017).