According to Newton et al. (2016), MLKL deficiency improves survival following kidney ischaemia-reperfusion injury, loss of MLKL provides significant protection against TNF (500 μg/kg body weight)-induced body temperature increase, and MLKL deficiency weakly regulates the increase in G-CSF, IL-6, and CXCL1 levels. This evidence concerns the gene IL6 and urogenital neoplasm.