In addition, Axl lead to EGFR-TKIs resistant by increasing expression and forming a hetero-dimerization with EGFR and inhibition of Axl could prevent or overcome acquired resistance to EGFR-TKIs in EGFR-mutated lung cancer (Zhang et al., 2012; Vouri et al., 2016). The gene discussed is AXL; the disease is lung cancer.