Of particular importance are inhaled corticosteroids (e.g. budesonide [AstraZeneca, 2006], mometasone [Merck Sharp and Dohme Corp, 2018] fluticasone [GlaxoSmithKline, 2017] beclomethasone [Teva Respiratory, 2017], and corticosteroids (e.g., prednisolone, methylprednisolone) [Bergmann et al., 2012; Pfizer, 2018]+, which are foundational treatment for asthma, are undergo significant metabolism by CYP3A4. The gene discussed is CYP3A4; the disease is asthma.