Recent studies have indicated that SIRT2 is implicated in several aging-related neurodegenerative diseases, and the fact that its expression increases not only with age but also in PD models suggests its key role in this particular disease (Harting and Knöll, 2010; Maxwell et al., 2011; Poulose and Raju, 2015; Sun et al., 2018). The gene discussed is SIRT2; the disease is Parkinson disease.