3-[(2-methoxynaphthalen-1-yl)methyl]-7-[(pyridin-3-ylmethyl)amino]-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one (ICL-SIRT078), a substrate-competitive SIRT2 inhibitor is recovered as a candidate neuroprotective agent in an in vitro PD model. This evidence concerns the gene SIRT2 and Parkinson disease.