Alzheimer’s disease (AD), the most dominant form of dementia, accounting for 60–80% of dementia cases, is a multifactorial neurodegenerative disease characterized by the accumulation of amyloid-β (Aβ; plaques) outside neurons and the hyperphosphorylation of tau protein and neurofibrillary tangles (NFTs) inside the neurons in the brain, which lead to cognitive deficit, memory loss, and then neuron death. Here, MAPT is linked to Alzheimer disease.