MAPT and Cognitive impairment: Recent studies have demonstrated that maternal resveratrol supplementation and vitamin D combined with resveratrol could prevent cognitive impairment in SAMP8 mice offspring through amyloidogenic pathways, neuroinflammation, tau phosphorylation, epigenetic changes, and cell signaling pathways (Cheng et al., 2017; Izquierdo et al., 2019).