Indeed, it was found that treatment with the α7 nAChR agonists A-582941, PNU-282987, AR-R17779, and ABBF improved learning and memory in Alzheimer’s disease animal models (Van Kampen et al., 2004; Boess et al., 2007; Medeiros et al., 2014; Vicens et al., 2017; reviewed in Foucault-Fruchard and Antier, 2017). This evidence concerns the gene CHRNA7 and Alzheimer disease.