Similarly, the effect of PNU282 can be attributed to either up-regulation of α7 nAChRs or decreased production of Aβ peptides, since another α7-selective agonist DMXBA suppressed γ-secretase activity in solubilized fractions of human neuroblastoma cells and transgenic mouse brain (Takata et al., 2018). The gene discussed is CHRNA7; the disease is neuroblastoma.