In conjunction with different colors of reporter fluorescence such as GFP, RFP, BFP, and iRFP, and functional fluorescent probes including genetically encoded sensors for Ca2+, voltage, and neurotransmitters (Chen et al., 2013; Marvin et al., 2013, 2019; Dana et al., 2016; Jing et al., 2018; Patriarchi et al., 2018; Sun et al., 2018; Abdelfattah et al., 2019; Inoue et al., 2019), the multiplexable virus infection systems will allow for in vivo interrogation of complex overlapping neural circuits in a single animal. This evidence concerns the gene RNF112 and viral infectious disease.