The SNP mutations could change the activity of lncRNAs transcriptional regulatory region and affect the expression of lncRNAs by changing the secondary structure of lncRNAs to obtain or lose the binding site of miRNAs, thus affecting the development, metastasis, and prognosis of tumor.22, 23, 24 The biological function of the secondary structure and the miRNA binding ability of the SNPs of the LINC00520 were predicted using the lncRNASNP2 database (http://bioinfo.life.hust.edu.cn/lncRNASNP) and the RNAfold website (http://rna.tbi.univie.ac.at/cgi-bin/RNAWebSuite/RNAfold.cgi). The gene discussed is LINC00520; the disease is neoplasm.