Compared with rs619586 A allele, the expression of MALAT1 in individuals carrying rs619586 G allele was lower, which might be related to the decreased susceptibility to BC.20 The G risk gene of rs6983267 site of lncRNA CCAT2 could increase the expression of CCAT2, which was related to the risk of colorectal cancer.21 The results showed that the genotype GG at rs12880540 site significantly increased the risk of BC compared with the genotype TT. This evidence concerns the gene MALAT1 and breast cancer.