Neurodegenerative diseases are associated with misfolded proteins that tend to form aggregates—the archetypal example being the prion diseases.41 The key feature in the development of a prion disease is the template‐assisted conversion of the normal cellular protein, PrPC, to the misfolded form, PrPSc, linked to disease.42 Thus, prion diseases can be idiopathic, inherited through mutations in the prion protein gene, or acquired through infection. The gene discussed is PRNP; the disease is prion disease.