Lynch syndrome (LS), previously called hereditary nonpolyposis colorectal cancer (HNPCC), is a cancer predisposition syndrome with a dominant inheritance caused by pathogenic (path_) germline variants in the DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6, and PMS2 [1]. This evidence concerns the gene MSH2 and hereditary nonpolyposis colon cancer.