The typical AIP mutation-positive (AIPmut) phenotype is characterized by a young patient presenting with a large invasive growth hormone (GH)-secreting PitNET that is refractory to conventional treatments (1,3–5,9–11), with AIPmut somatotropinomas being responsible for 29% of pituitary gigantism cases (12). This evidence concerns the gene AIP and growth hormone-producing pituitary gland neoplasm.