This is a common feature of cancer cell lines (30), but the degree of change observed here was unexpected, and we suspect this effect is secondary to changes in levels of 3′ processing factors as a consequence of inhibiting cytoplasmic cap methylation, notably PABPN1, whose mRNA and protein levels are increased 2- and 1.7-fold, respectively (Supplementary Table S1, Supplementary Figure S4), in ΔN-RNMT expressing cells. This evidence concerns the gene PABPN1 and cancer.