Interestingly, we disclosed a statistically significant decrease of MUC5B rs35705950 GT, TT and T frequencies in patients with ASSD-ILD + compared to the whole cohort of patients with ILD unrelated to ASSD (GT: 19.7% versus 53.4%, p < 0.0001; TT: 0.7% versus 9.1%, p < 0.0001; T: 10.6% versus 35.8%, p < 0.0001) (Supplementary Table 1). This evidence concerns the gene MUC5B and interstitial lung disease.