For this purpose, we compared human cells with different p53 status: HCT116 colon carcinoma cells with wild-type p53 and HCT116 variant with the TP53 gene depletion due to its bi-allelic knockout [31] as well as RKO colon carcinoma cells (wild-type p53) and RKO variant (RKO-E6) that expresses the human papillomavirus E6 protein which binds to and inactivates p53 protein. This evidence concerns the gene TP53 and colon carcinoma.