Results presented here suggest that ABA is the endogenous hormone in charge of AMPK activation and imply that low-dose oral ABA may alleviate insulin deficiency, as occurs in hypoinsulinemic TRPM2 KO mice, or contribute to reduce the dose of insulin required to control hyperglycemia in insulin-resistant T2D and in insulin-deficient T1D. Here, INS is linked to type 2 diabetes mellitus.