For example, expression levels of the transcription factor JUN, the translation initiation factor EIF1, the ubiquitin protein UBC, the interleukin 4 receptor IL4R, and the MHC class II co-receptor CD74 were associated with slow reduction of CLL cell numbers, while the p53 cofactor DDX5, the TNF receptor protein CD27, and the signaling protein CD24 were associated with fast reduction. Here, TP53 is linked to B-cell chronic lymphocytic leukemia.