NFKB1 and B-cell chronic lymphocytic leukemia: Most notably, we observed downregulation of NF-κB signaling and loss of B-cell surface markers in CLL, suggesting these are key contributors to the progressive reduction of the CLL cell fraction over time, and we observed a surprising degree of transcriptional change in non-CLL immune cells concomitant with an increase in the CD8+ T cell fraction.