NFKB1 and B-cell chronic lymphocytic leukemia: Integrative bioinformatic analysis of the resulting dataset identify a consistent regulatory program of ibrutinib-induced changes that is shared across all patients: Within the first days after the start of ibrutinib treatment, CLL cells display reduced NF-κB binding, followed by reduced activity of lineage-defining transcription factors, and erosion of CLL cell identity.