Additionally, proteins are the necessary substance to participate in lives’ activities and disease progression as well, which were closely related with lncRNA and miRNA etc. Delta-like ligand 4 (DLL4), one of the ligands of Notch receptors, is predominantly expressed in the endothelial cells and has been shown to play a pivotal role in regulating tumor angiogenesis. Here, DLL4 is linked to neoplasm.