Additionally, cytoplasmic HER4 expression was associated with the epithelioid variant (r: 0.4235; p: 0.0090) and desmoplasia (r: 0.4958; p: 0.0018) in skin tumors and with the epithelioid variant in oral lesions (r: − 0.4643, p: 0.0452). Here, ERBB4 is linked to skin neoplasm.