Exposure to PEPs prolonged QT, altered expression of key repolarizing potassium channels in the right ventricle (Kv1.5, Kv4.2) and left ventricle (Kv7.1), and increased arrhythmia long after cessation of exposures, indicating PEPs induced spontaneous tachyarrhythmia and electrical remodeling. The gene discussed is KCNQ1; the disease is cardiac arrhythmia.