For the underlying stages of liver fibrosis, the results were similar to those observed for VL (F2 = ArgValAlaAla+/+vs. heterozygous a: p: 0.0230) (F3-F4 = ArgValAlaAla+/+ vs. ArgValValAla+/+: p: 0.0121) and liver enzymes, except GGT, (ALT - F2 = ArgValAlaAla+/+ vs. heterozygous: p: 0.0227), (ALT - F3 - F4 = ArgValAlaAla+/+ vs. heterozygous: p: 0.0571; ArgValAlaAla+/+ vs ArgValValAla+/+: p: 0.0280), (AST - F2 = ArgValAlaAla+/+ vs. heterozygous: p: 0.0303), (AST - F3-F4 = ArgValAlaAla+/+ vs. heterozygous: p: 0.0212; ArgValAlaAla+/+ vs. ArgValValAla+/+: p: 0.0457) (Fig. 6a-d). The gene discussed is GPT; the disease is Hepatic fibrosis.