The haplotype analysis revealed that Grs45544231 Trs12922061 Ars3112612 and Grs45544231 Crs12922061 Ars3112612 haplotypes in the CASC16 gene were found to reduce risk of breast cancer (OR = 0.82, 95% CI = 0.69–0.98, p = 0.025; OR = 0.85, 95% CI = 0.73–0.99, p = 0.039; respectively; Table 7). This evidence concerns the gene CASC16 and breast cancer.