CD4 and HIV-1 infection: Notably, Nt1 and Nt2 controllers did not differ significantly in terms of viral loads, CD4+ T cells, duration of HIV-1 infection, or neutralizing Ab breadth, although Nt2 individuals tended to display a higher potency of neutralization than Nt1 controllers for 6 of the 11 tier 2 HIV-1 pseudoviruses tested (Figures 1B, S1B, and S1C; Table S1).