Nevertheless since p53 codon 72 polymorphism is a strong apoptosis inducer [55] we may suggest that under p53 activation followed by anti-CD3/CD28 stimulation Treg, Teff and activated Teff subsets may have increased susceptibility to apoptosis in PBMC of T1D patients harboring the variant. The gene discussed is TP53; the disease is type 1 diabetes mellitus.