P53 gene mutations were discovered in human RA synoviocytes [25–27], a TP53 codon 72 *Arg/*Arg polymorphism was found associated with a higher risk for inflammatory bowel disease development [28] and autoimmune thyroid disease [29,30] and detected at high prevalence in type 1 diabetes patients with age at onset <6 years with a strong linear correlation in females [31]. This evidence concerns the gene TP53 and inflammatory bowel disease.