The functional enrichment assay indicated that the most represented biological process among these proteins was the carboxylic acid metabolic process considering the GO database classification (GO:0019752, FDR: 7.88e-17), and in the pie chart depicting the functional classification (Fig 5B), it can be observed that the proteins that decrease their interaction with Akt in MetS condition are mainly those related to energy metabolism (71.1%). This evidence concerns the gene AKT1 and metabolic syndrome.