Significant between-group differences in serum IgE levels were observed for both total and Der p 1-specific IgE, with the allergic asthma group presenting significantly higher levels of total IgE (mean, 1702.3 KU/L) and Der p1-specific IgE levels (15.5 KU/L) than the nonallergic group and healthy controls. The gene discussed is IGHE; the disease is allergic asthma.