Similarly, a significantly higher proportion of participants with anti-DENV IgM positive than negative urine had clinical signs of severe disease including low serum albumin (40.6% vs. 23.1%, WS = 0.18, CI95 0.09–0.26), thrombocytopenia (53.1% vs. 30.1%, WS = 0.23, CI95 0.14–0.31), aspartate transaminase (median: 119 vs. 66, P<0.001) and alanine transaminase (median: 82 vs. 58, P<0.001). The gene discussed is CD40LG; the disease is Thrombocytopenia.