Rotavirus virions are double-stranded RNA particles classified by six nonstructural proteins (NSP1–NSP6) and six structural proteins (VP1–VP4, VP6 and VP7) which form a three-layered structure of inner core, inner capsid, and outer capsid.16,17 During infection, VP4 is cleaved via proteolysis into VP8* and VP5* fragments, which are required for cellular infection.18 The rotavirus strains that most frequently infect humans can be grouped into three P genotypes, P[4], P[6], and P[8], each defined by slightly different VP8* protein structures.19,20. The gene discussed is SH2D3A; the disease is infection.