c-Met plays important roles in regulation of cell growth, survival, and metastasis.8 Abnormal activation of c-Met signaling pathway was detected in many malignant tumors, including gastric cancer, lung cancer, esophageal cancer, breast cancer, liver cancer, colon cancer, prostate cancer, pancreatic cancer, kidney cancer, ovarian cancer, glioma, melanoma, osteosarcoma, and various cancers. The gene discussed is MET; the disease is osteosarcoma.