The latter is due to a strong reduction in blood glucose in response to SGLT2 inhibition in these models, which together with the associated lowering in GFR, reduces filtered glucose load to a similar extent as the drugs inhibit proximal tubular glucose reabsorption, such that glucosuria and urine flow rate remain largely unchanged, consistent with mathematical modeling (Layton, Vallon, & Edwards, 2016). Here, SLC5A2 is linked to Glycosuria.