RYR2 and catecholaminergic polymorphic ventricular tachycardia: There are more than 150 unique, mostly missense, pathogenic variants identified in the RYR2 gene as the underlying cause for CPVT (Ackerman et al., 2011; Leenhardt et al., 2012; Priori et al., 2001; Stenson, Ball, & Mort, 2003; Stenson et al., 2014).