Luu's study also substantiated that low‐magnitude mechanical signals (90 Hz, 0.2 g) could reduce adipogenic differentiation of mesenchymal stem cells with down‐regulation of PPARγ and C/EBPα in an obesity mouse model.47 Similar to in vivo data, the effect of HMB alone on adipogenesis was not remarkable, with significant reduction in ORO signals and reduced expression of PPARγ only. The gene discussed is CEBPA; the disease is obesity due to melanocortin 4 receptor deficiency.