In tumour cells, mitochondrial HK2 not only promotes a aerobic glycolysis, but also increases resistance to cell death signals.11 Thus, the increased HK2 expression and its binding to mitochondria facilitates not only increased aerobic glycolysis and lactate production but also the channelling of glycolytic substrates into biosynthetic pathways for which mitochondria play a crucial role, so it seems that understanding the relationship between mitochondrion and glycolysis is important to explore how it performs related functions. The gene discussed is HK2; the disease is neoplasm.