HK2 has been shown to be overexpressed in many cancers and is considered a predictor of poor prognosis for HCC, breast and gastric cancer.41, 42 Many cancer studies have demonstrated the importance of HK2 in many cell life activities, including proliferation, metastasis and apoptosis.43 After CTB treatment, we found that lactate production and glucose consumption in HCC cells dramatically decreased. Here, HK2 is linked to cancer.